EXPRESS SCRIPTS ACQUIRES INDUSTRY LEADING CDHP ACCOUNT ADMINISTRATOR

ConnectYourCare Aids Strategy of Enabling Better Health and Value at the Consumer Level

ST. LOUIS, October 11, 2007 - Pharmacy benefit manager Express Scripts, Inc., (NASDAQ: ESRX) today announced the acquisition of ConnectYourCare, L. L. C., one of the nation’s leading consumer directed health plan (CDHP) account administrators, from privately-held Revolution Health. Terms of the transaction were not disclosed.

ConnectYourCare, based near Baltimore, MD, features a proprietary account administration platform built specifically to administer health accounts, including health savings accounts (HSA), health reimbursement arrangements (HRA), flexible spending accounts (FSA) and dependent care and retiree medical reimbursement accounts.

The company offers a robust end-to-end solution featuring enrollment and account funding, multiple accounts “stacked” on a single debit card backed by state-of-the-art auto-substantiation capabilities, HSA investment options, web-based consumer decision support and wellness tools and customer service.

The company will operate as a stand-alone unit serving the growing CDHP market, connecting any employer, health plan, or third party administrator and financial institution for seamless account administration. Forrester Research gave ConnectYourCare a top ranking in its 2006 evaluation of CDHP platforms in the following areas: business process outsourcing, education and decision support, market presence, product strategy, payment administration, integration with PBMs, and employer administration of accounts.

“ConnectYourCare’s award-winning account administration platform and seasoned CDHP experts are an exciting addition to Express Scripts, strengthening our ability to enable better health and value at the consumer level,” said George Paz, Express Scripts’ chief executive officer.

“In addition to the CDHP growth opportunity, ConnectYourCare represents a significant extension of our commitment to take our business model of alignment with plan sponsors and members to the next stage. Our success in encouraging consumers to increase the use of generic drugs demonstrates that empowered, educated consumers, given convenient, state-of-the-art tools like those of ConnectYourCare, can unlock great value in actively managing their health,” said Paz.

Express Scripts provides ConnectYourCare with greatly enhanced access to employers, health plans, and third party administrators. ConnectYourCare complements Express Scripts’ consumer-focused initiatives, including its CDHP offerings.

“We’re excited by the opportunity Express Scripts provides to realize the ConnectYourCare vision of delivering best-in-class fully portable CDHP solutions. We are impressed by Express Scripts’ commitment to empowering consumers and look forward to taking full advantage of Express Scripts’ distribution capabilities,” said Jamie Spriggs, ConnectYourCare co-founder and president.

“Both companies have value propositions that are built on the economic forces brought about by consumerism. Our philosophies are consistent in believing that consumerism will remove the friction in the healthcare system, aligning constituents to resemble vendor/consumer systems in other industries. Having a pharmacy-focused approach to the market gives us a unique perspective that translates into capabilities which will clearly drive hard savings for employers,” added Spriggs.

Express Scripts already supports CDHPs by providing seamless medical and pharmacy claims data integration to more than 50 national, regional and local carriers, health plans and third-party administrators. The company also provides plan sponsors with a comprehensive consumer education program called ChoiceMatters. As the nation’s most used employee benefit, the pharmacy benefit is geared for an active consumer role, especially because there are many prescription drug alternatives available to treat most conditions.

About Express Scripts

Express Scripts, Inc. is one of the largest PBM companies in North America, providing PBM services to over 50 million members. Express Scripts serves thousands of client groups, including managed-care organizations, insurance carriers, employers, third-party administrators, public sector, and union-sponsored benefit plans.

Express Scripts provides integrated PBM services, including network-pharmacy claims processing, home delivery services, benefit-design consultation, drug-utilization review, formulary management, disease management, and medical-and drug-data analysis services. The Company also distributes a full range of injectable and infusion biopharmaceutical products directly to patients or their physicians, and provides extensive cost-management and patient-care services.

Express Scripts is headquartered in St. Louis, Missouri. More information can be found at http://www.express-scripts.com.

Express Scripts Contacts
Media Contact:
Steve Littlejohn
314.996-0981
slittlejohn@express-scripts.com

Investor Contact:
David Myers
314-810-3115
dmyers@express-scripts.com

About ConnectYourCare

ConnectYourCare’s benefit delivery platform provides a pathway for migration to consumer directed health, supplying tools for employees to better manage their healthcare choices and a vehicle for employers to realize healthcare cost containment. ConnectYourCare solutions include a multi-purse health payment card and Internet portal for employees to manage tax-advantaged accounts and related investments, completely transparent financial claims adjudication, multi-channel access to ConnectYourCare’s customer support services, and comprehensive medical information and decision-support tools with a focus on wellness. Additional information is available at http://www.ConnectYourCare.com.

ConnectYourCare Contact
Beverly Regester
410.891.1018
beverly.regester@connectyourcare.com

SAFE HARBOR STATEMENT

This press release contains forward-looking statements, including, but not limited to, statements related to the Company’s plans, objectives, expectations (financial and otherwise) or intentions. Actual results may differ significantly from those projected or suggested in any forward-looking statements. Factors that may impact these forward-looking statements include but are not limited to:

• uncertainties associated with our acquisitions, which include integration risks and costs, uncertainties associated with client retention and repricing of client contracts, and uncertainties associated with the operations of acquired businesses
• costs and uncertainties of adverse results in litigation, including a number of pending class action cases that challenge certain of our business practices
• investigations of certain PBM practices and pharmaceutical pricing, marketing and distribution practices currently being conducted by regulatory agencies including the Department of Labor, and various state attorneys general
• changes in industry pricing benchmarks such as average wholesale price (“AWP”) and average manufacturer price (“AMP”) , which could have the effect of reducing prices and margins, including the impact of a proposed settlement in a class action case involving First DataBank, an AWP reporting service
• uncertainties regarding the implementation of the Medicare Part D prescription drug benefit, including the financial impact to us to the extent that we participate in the program on a risk-bearing basis, uncertainties of client or member losses to other providers under Medicare Part D, and increased regulatory risk
• uncertainties associated with U.S. Centers for Medicare & Medicaid’s (“CMS”) implementation of the Medicare Part B Competitive Acquisition Program (“CAP”), including the potential loss of clients/revenues to providers choosing to participate in the CAP
• increased compliance relating to our contracts with the DoD TRICARE Management Activity and various state governments and agencies
• our ability to maintain growth rates, or to control operating or capital costs
• continued pressure on margins resulting from client demands for lower prices, enhanced service offerings and/or higher service levels, and the possible termination of, or unfavorable modification to, contracts with key clients or providers
• competition in the PBM and specialty pharmacy industries, and our ability to consummate contract negotiations with prospective clients, as well as competition from new competitors offering services that may in whole or in part replace services that we now provide to our customers
• results in regulatory matters, the adoption of new legislation or regulations (including increased costs associated with compliance with new laws and regulations), more aggressive enforcement of existing legislation or regulations, or a change in the interpretation of existing legislation or regulations
• the possible loss, or adverse modification of the terms, of relationships with pharmaceutical manufacturers, or changes in pricing, discount or other practices of pharmaceutical manufacturers or interruption of the supply of any pharmaceutical products
• the possible loss, or adverse modification of the terms, of contracts with pharmacies in our retail pharmacy network
• the use and protection of the intellectual property we use in our business
• our leverage and debt service obligations, including the effect of certain covenants in our borrowing agreements
• our ability to continue to develop new products, services and delivery channels
• general developments in the health care industry, including the impact of increases in health care costs, changes in drug utilization and cost patterns and introductions of new drugs
• increase in credit risk relative to our clients due to adverse economic trends
• our ability to attract and retain qualified personnel
• other risks described from time to time in our filings with the SEC

We do not undertake any obligation to release publicly any revisions to such forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.